Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer
Identifieur interne : 001B74 ( Main/Exploration ); précédent : 001B73; suivant : 001B75Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer
Auteurs : Amanda W. Lund [États-Unis] ; Terry R. Medler [États-Unis] ; Sancy A. Leachman [États-Unis] ; Lisa M. Coussens [États-Unis]Source :
- Cancer discovery [ 2159-8274 ] ; 2015.
Abstract
Skin is a highly ordered immune organ that coordinates rapid responses to external insult while maintaining self-tolerance. In healthy tissue, lymphatic vessels drain fluid and coordinate local immune responses; however, environmental factors induce lymphatic vessel dysfunction, leading to lymph stasis and perturbed regional immunity. These same environmental factors drive the formation of local malignancies, which are also influenced by local inflammation. Herein, we discuss clinical and experimental evidence supporting the tenet that lymphatic vessels participate in regulation of cutaneous inflammation and immunity, are important contributors to malignancy and potential biomarkers and targets for immunotherapy.
Url:
DOI: 10.1158/2159-8290.CD-15-0023
PubMed: 26552413
PubMed Central: 4707138
Affiliations:
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Lund</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Oregon Health & Science University, Portland, OR 97239</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Department of Dermatology, Oregon Health & Science University, Portland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Knight Cancer Institute, Oregon Health & Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Medler, Terry R" sort="Medler, Terry R" uniqKey="Medler T" first="Terry R." last="Medler">Terry R. 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In healthy tissue, lymphatic vessels drain fluid and coordinate local immune responses; however, environmental factors induce lymphatic vessel dysfunction, leading to lymph stasis and perturbed regional immunity. These same environmental factors drive the formation of local malignancies, which are also influenced by local inflammation. Herein, we discuss clinical and experimental evidence supporting the tenet that lymphatic vessels participate in regulation of cutaneous inflammation and immunity, are important contributors to malignancy and potential biomarkers and targets for immunotherapy.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Oregon</li></region></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Lund, Amanda W" sort="Lund, Amanda W" uniqKey="Lund A" first="Amanda W." last="Lund">Amanda W. Lund</name></region><name sortKey="Coussens, Lisa M" sort="Coussens, Lisa M" uniqKey="Coussens L" first="Lisa M." last="Coussens">Lisa M. Coussens</name><name sortKey="Coussens, Lisa M" sort="Coussens, Lisa M" uniqKey="Coussens L" first="Lisa M." last="Coussens">Lisa M. Coussens</name><name sortKey="Leachman, Sancy A" sort="Leachman, Sancy A" uniqKey="Leachman S" first="Sancy A." last="Leachman">Sancy A. Leachman</name><name sortKey="Leachman, Sancy A" sort="Leachman, Sancy A" uniqKey="Leachman S" first="Sancy A." last="Leachman">Sancy A. Leachman</name><name sortKey="Lund, Amanda W" sort="Lund, Amanda W" uniqKey="Lund A" first="Amanda W." last="Lund">Amanda W. Lund</name><name sortKey="Lund, Amanda W" sort="Lund, Amanda W" uniqKey="Lund A" first="Amanda W." last="Lund">Amanda W. Lund</name><name sortKey="Lund, Amanda W" sort="Lund, Amanda W" uniqKey="Lund A" first="Amanda W." last="Lund">Amanda W. 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